Mexican Lasagna

This post may contain affiliate links. Read my full disclosure policy.

With layers of corn tortillas, spiced ground beef, roasted tomato salsa, and plenty of cheese, this Mexican lasagna (aka stacked enchiladas) is one of those dinners everyone looks forward to.

Serving slice of Mexican lasagna.

You know when you make a dish for the first time and your whole family loves it—and it’s clear it’s going straight into the regular rotation? That’s how I felt the first time I made this Mexican lasagna.

It’s a stacked, layered take on beef enchiladas (sometimes called stacked enchiladas) made with corn tortillas, seasoned ground beef, roasted tomato salsa, and plenty of cheese, all baked together like a lasagna, but much easier to pull off.

What I love most is that it delivers all the flavor of classic enchiladas without the extra step of rolling and filling each one. It’s hearty, satisfying, and great for feeding a crowd. And if you make the sauce ahead of time, it comes together easily enough for a weeknight, too.

“Fantastic! Served with sliced avocados and black beans. Super easy, and the sauce is divine.”

Bethany

What You’ll Need To Make Mexican Lasagna

stacked beef enchiladas ingredients
  • Ground Beef: The main protein that fills the layers of the lasagna. 90% lean beef is ideal for its lower fat content (there is no need to drain the fat).
  • Baking Soda: Used for tenderizing the beef.
  • Tomatoes, Onions, Garlic: Roasted and blended to make a vibrant sauce, essentially a roasted tomato salsa.
  • Cumin, Cayenne Pepper, Chipotle Chili Pepper: This spice trio infuses the dish with earthy, spicy, and smoky notes, giving the enchiladas bold Mexican flavor.
  • Cilantro: Adds a pop of herbal freshness and color. Feel free to leave it out if you’re not a fan.
  • Yellow Corn Tortillas: The foundation for the stacked enchiladas, these tortillas are cut into quarters for easy layering.
  • Mexican Blend Cheese: A mix of cheeses that includes cheddar and Monterey Jack, this blend melts beautifully, creating gooey, stretchy layers that bind the enchiladas together.
  • Jump to the printable recipe for precise measurements

Step-by-Step Instructions

Step 1: Tenderize the Beef. To begin, mash the ground beef and the baking soda in a large bowl and let sit on the counter for about 20 minutes. The baking soda raises the pH of the meat, helping to lock in moisture and make the beef melt-in-your-mouth tender.

mashed ground beef and baking soda.

Step 2: Make the Sauce. Toss the tomatoes, onion, and garlic with the oil right on a foil-lined baking sheet. Broil until softened and lightly charred, 12 to 15 minutes, giving them a quick stir if they start to brown too fast.

Transfer everything, including the juices, to a food processor. Add the salt, cumin, and cayenne and pulse until slightly chunky. Add the cilantro and pulse again just until chopped.

Step 3: Make the seasoned ground beef filling. Heat the oil in a large skillet over high heat. Add the beef and cook, stirring frequently and breaking into pieces, until just slightly pink, about 2 minutes. Add the spices and salt, then cook for about 5 minutes more, or until the meat is cooked through.

browned ground beef in skillet.

Step 4: Assemble. Line a greased baking dish with a slightly overlapping layer of tortillas. Spoon half of the beef (with any juices) over top, then half of the sauce. Repeat with another layer of tortillas, the remaining beef and sauce, and about one-third of the cheese. Top with a final layer of tortillas, spread the reserved sauce over them, and finish with the remaining cheese. (The unbaked casserole can be refrigerated for up to 2 days or frozen for up to 3 months.)

Step 5: Bake and serve. Place the Mexican lasagna in the oven and bake, uncovered, for 30 to 35 minutes, or until heated through and the cheese is completely melted. Slice into squares and enjoy!

baked stacked enchiladas fresh out of the oven.

Mexican Lasagna Video Tutorial

More South of the Border Recipes You’ll Love

Print

Mexican Lasagna

Serving slice of Mexican lasagna.
A hearty Mexican lasagna with all the classic enchilada flavors, layered and baked until bubbly.
Servings: 8
Prep Time: 40 minutes
Cook Time: 35 minutes
Total Time: 1 hour 15 minutes

Ingredients 

For the Beef

  • pounds 90% lean ground beef
  • ½ teaspoon baking soda
  • 2 tablespoons vegetable oil
  • teaspoons ground chipotle chile pepper (see note)
  • teaspoons ground cumin
  • ¾ teaspoon salt

For the Sauce

  • 4 large vine-ripened tomatoes (about 1.3 lb/590 g), quartered
  • 2 medium yellow onions, cut into ½-inch wedges
  • ¼ cup vegetable oil
  • 6 cloves garlic, peeled
  • 2 teaspoons salt
  • 1 teaspoon ground cumin
  • teaspoon cayenne pepper
  • ¼ cup cilantro leaves

For Assembling

  • 10 (8-in/20-cm) yellow corn tortillas, cut into quarters (I use Mission brand)
  • 4 cups (12 oz) shredded Mexican blend cheese

Instructions

  • In a large bowl, combine the ground beef and the baking soda. Mix with your hands until evenly combined. Let sit on the counter for 20 to 30 minutes.
  • While the beef sits, prepare the sauce. Set an oven rack about 5 inches beneath the heating element and preheat the broiler. Line a rimmed baking sheet with aluminum foil.Toss the tomatoes, onions, and garlic with the vegetable oil directly on the prepared baking sheet. Broil until softened and charred, 12 to15 minutes (if the vegetables are browning too quickly, give them a quick stir with a rubber spatula). Transfer the vegetables and juices to a food processor fitted with the metal blade. Add the salt, cumin, and cayenne pepper and pulse until just slightly chunky. Add the cilantro and pulse until the cilantro is chopped. Set the sauce aside.
  • Heat the oil in a large skillet over high heat. Add the beef and cook, stirring frequently and breaking into pieces, until just slightly pink, about 2 minutes. Add the chili powder, cumin, and salt and cook, stirring occasionally, for 4 to 5 minutes more, or until cooked through.
  • To assemble: Preheat oven to 350°F (175°C) and move the oven rack to the center position. Lightly oil a 9x13-in (22x33-cm) glass or ceramic baking dish.
  • Set aside 1 cup (240 ml) of the sauce for the top of the casserole. (You want to ensure that you have enough to cover the top layer of tortillas, otherwise they won't cook through.)
  • Line the bottom of the prepared baking dish with a layer of tortillas, overlapping them slightly. Spoon half of the beef (and any juices) over the tortillas. Top with half of the sauce and ⅓ of the cheese. Repeat with another layer of tortillas, the remaining beef, remaining sauce, and ⅓ of the cheese. Top with the remaining tortillas. Spread the reserved sauce over the tortillas and cover completely. Sprinkle the remaining cheese evenly over top.
  • Bake, uncovered, for 30 to 35 minutes, or until the casserole is heated through and the cheese is completely melted.

Notes

  • Ground chipotle chile pepper is smoky and hot and makes this dish a little spicy. For a milder dish, replace the ground chipotle chile pepper with ground ancho chili pepper, which isn't as hot.
  • Make-Ahead/Freezing Instructions: The casserole can be prepared ahead of time, tightly covered with foil, and refrigerated for up to two days or frozen for up to 3 months before baking (if frozen, defrost in the refrigerator before cooking). It can also be fully baked, tightly covered with foil, and refrigerated for up to two days or frozen for up to 3 months. To reheat: defrost if necessary and heat the covered casserole in a 350°F oven for about 30 minutes, or until hot. If you'd rather reheat individual servings, small portions can be zapped in the microwave for 1 to 2 minutes.

Nutrition Information

Calories: 491kcalCarbohydrates: 21gProtein: 30gFat: 32gSaturated Fat: 11gCholesterol: 96mgSodium: 608mgFiber: 3gSugar: 4g

This website is written and produced for informational purposes only. I am not a certified nutritionist and the nutritional data on this site has not been evaluated or approved by a nutritionist or the Food and Drug Administration. Nutritional information is offered as a courtesy and should not be construed as a guarantee. The data is calculated through an online nutritional calculator, Edamam.com. Although I do my best to provide accurate nutritional information, these figures should be considered estimates only. Varying factors such as product types or brands purchased, natural fluctuations in fresh produce, and the way ingredients are processed change the effective nutritional information in any given recipe. Furthermore, different online calculators provide different results depending on their own nutrition fact sources and algorithms. To obtain the most accurate nutritional information in a given recipe, you should calculate the nutritional information with the actual ingredients used in your recipe, using your preferred nutrition calculator.

Gluten-Free Adaptable Note

To the best of my knowledge, all of the ingredients used in this recipe are gluten-free or widely available in gluten-free versions. There is hidden gluten in many foods; if you're following a gluten-free diet or cooking for someone with gluten allergies, always read the labels of your ingredients to verify that they are gluten-free.

4.86 from 230 votes

Add a Comment

Rate the recipe: 5 stars means you loved it, 1 star means you really disliked it




This site uses Akismet to reduce spam. Learn how your comment data is processed.

415 Comments

  • 5 stars
    I don’t ever post reviews but made this for the family and they loved it. Didn’t change a thing, it was delicious!

  • 5 stars
    Delicious! My first recipe from your site but not the last! Looking forward to getting your book. I would like to swap out chicken for the beef. I am wondering how much chicken I should prepare for this recipe. Also, did you buy the pre-shredded Mexican blend cheese or did you shred it yourself?

    • Hi Denise, So glad you enjoyed it! If you’re planning to use ground chicken, use the same amount. If you’re planning to use cooked chicken, I’m guessing you’ll need about 3 cups of shredded meat. And I use the pre-shredded – makes it easy. 🙂

  • 5 stars
    Absolutely delicious!!! Followed the recipe to a tee for last night’s dinner. My family said that it was better than a fine Mexican restaurant. Jennifer, I am so grateful for your website and cookbook.

  • 5 stars
    This was a great change to both a lasagna, and Mexican tacos. The flavours were great and the texture delicate. I adjusted the recipe by putting both the meat and sauce (still taking out 1 cup) together to help the flavours come together. Plus I needed to run and pick up my son while I was making this, so it helped with refrigerator space. I also added one canned chipotle pepper and juice in with the sauce as I didn’t have chipotle chili powder. The roasted tomato, onion and garlic sauce I will make again as a warm salsa! Yippee!

  • 5 stars
    Delicious! I will definitely be making this again. We topped each serving with sour cream and thinly cut scallions! Yum!

  • Hi Jenn,
    Anxious to try your Mexican Lasagna.
    I was just curious if I could use your baking soda hamburger mix when bbqing hamburgers? Thank you!!!!!!

    • Hi Cheryl, With things like burgers and meatloaf, bread crumbs and/or eggs are often added (which will tenderize them), so the baking soda isn’t necessary.

  • Can flour tortillas be used ?

    • Hi Desiree, I think corn tortillas work much better here. That said, some readers have commented that they’ve use flour tortillas with success.

    • 5 stars
      Hi Jenn, I’m not usually a reviewer, but wanted to report that this recipe works with two cans of diced tomatoes (no fresh tomatoes on hand). I apologize for reviewing with changes, but hope this may help others: I drained both cans into my food processor, then roasted the drained canned tomatoes with the onions, garlic and olive oil. After processing the roasted vegetables as written, I added a tiny squeeze of honey and gave it a quick pulse. This seemed to dissipate the very slight “canned” aftertaste.

      This was our twin daughters’ requested birthday dinner meal, along with the chocolate lover’s birthday cake from your cookbook. They loved everything! Thank you for all your recipes (which we enjoy often), but especially today, for helping me to have a fun and delicious birthday party in these challenging days – you are a real blessing. ❤️

      • So glad you enjoyed it and that the canned tomatoes worked out nicely — thanks for reporting back (and hope your daughters had a great birthday)! 🙂

  • 5 stars
    Wow, Jenn, I am so glad to have found this post as I am always looking for something new to try. And this Mexican Lasagna recipe you shared is delicious in every bite! We can just make the beef in advance, leave it chilled for later, and then do the assembling and the sauce when you are ready. Thanks for sharing this!

    • — Elizabeth Higgins
    • Reply
  • 5 stars
    I made this after having leftovers of Jenn’s roasted salsa. The flavors were very good, though my salsa was quite spicy so hubby & son couldn’t eat it. Loved the tenderized hamburger & it froze well, making nice lunches for work.

    • — Amber Y. Lizarraga
    • Reply
  • 5 stars
    Was excellent – Only a little changes. Made half again sauce, added black beans & black sliced olives to beef.
    All went well very good dish, sauce is excellent. use it now in other Tex-Mex dishes.